Elucidating and Manipulating the Mechanisms Behind Gene Expression
We’re interested in regulation of chemical kinetics in biological systems, especially in understanding how inherently stochastic gene expression dynamics are “tamed” to produce reliable cellular outcomes. A precise control of dynamic gene activity is important in preventing mis-regulation that could cause serious developmental defects.
The lab uses a combination of molecular experiments, quantitative live imaging, kinetic modeling and other fundamental engineering principles to obtain spatiotemporal control of gene activity. These interdisciplinary studies will provide important insights to general gene-expression phenomena that underlie development, metabolism, and disease.